Recommended dosing schedule for POLIVY (polatuzumab vedotin-piiq)*

POLIVY, bendamustine, and a rituximab product can be administered in any order on Day 1 of each cycle.

Dilute POLIVY to a final concentration of 0.72-2.7 mg/mL in an IV infusion bag with a minimum volume of 50 mL containing 0.9% Sodium Chloride Injection, USP; 0.45% Sodium Chloride Injection, USP; or 5% Dextrose Injection, USP.

*See additional dosing information below.

POLIVY+BR infusions: routine monitoring, with no requirement for hospitalization at time of administration 1

  • Patients should be monitored during the infusion and after the infusion is finished
  • Hospitalization may be required to manage select adverse events in some patients
  • See Dose Modifications for management guidelines for peripheral neuropathy, infusion-related reactions, and myelosuppression


Additional POLIVY dosing and administration information

Recommended prophylactic medications 1

Premedication for potential infusion-related reactions

If the patient was not already premedicated for a rituximab product, administer an antihistamine and an antipyretic at least 30 to 60 minutes prior to POLIVY for potential infusion-related reactions.

Prophylaxis for other potential adverse events

  • Administer prophylaxis for Pneumocystis jiroveci pneumonia and herpesvirus throughout treatment with POLIVY
  • Consider prophylactic G-CSF administration for neutropenia
  • Administer tumor lysis syndrome prophylaxis for patients at increased risk of tumor lysis syndrome

Administration requirements 1

  • Do not mix POLIVY with or administer through the same infusion line as other medicinal products
  • If a planned dose of POLIVY is missed, administer as soon as possible. Adjust schedule of administration to maintain a 21-day interval between doses
  • See full Prescribing Information for complete dosing and administration requirements
  • See full Prescribing Information for bendamustine and a rituximab product prior to initiation

G-CSF=granulocyte colony-stimulating factor.

Start treatment quickly, with a predictable treatment course

POLIVY is ready for infusion for adult patients with R/R DLBCL, NOS, after at least 2 prior therapies.


POLIVY Dosing and Administration Guide

Find detailed information on how to prepare and administer POLIVY.