Side effects most frequently seen in the trial

Everyone reacts differently to POLIVY, so it’s important to know what to expect.

The types of side effects seen in patients receiving POLIVY were similar to those of other cancer treatment regimens used in diffuse large B-cell lymphoma (DLBCL). Serious side effects included pneumonia, low white blood cell count accompanied by a fever, fever alone, and sepsis—a serious complication from infection.

Some of the most common side effects that were greater in the POLIVY group compared to the group that did not receive POLIVY were:

Blood and lymphatic system disorders

Low white blood cell count, which will make it more difficult for your body to fight infection

Anemia, or low hemoglobin or red blood cell count

Low platelet counts, which may cause an increased risk of bleeding

Nervous system disorders

Nerve problems in the arms and legs


Gastrointestinal disorders



General disorders

Infusion-related reaction


Decreased appetite



Upper respiratory tract infection


Weight loss

Metabolism and nutrition disorders

Low potassium, an important electrolyte for nerve and muscle cell functioning

Low albumin, a major protein in the body

Low calcium

These may not be all the side effects you may experience with POLIVY. Your doctor will help you identify and manage your side effects, so please be sure to inform your healthcare team of any symptoms and take all necessary tests. Please also see the full Prescribing Information for additional Important Safety Information

Preparing for Your POLIVY Infusion

Preparing for infusions with POLIVY™ (polatuzumab vedotin-piiq)

Understand what you can do to get ready for your treatment with POLIVY

Additional Resources

Additional resources for patients

Download a treatment guide and find links to organizations and support groups

Financial Support

POLIVY™ (polatuzumab vedotin-piiq) icon for financial support

Learn about financial assistance and other resources to help you access POLIVY