POLIVY (polatuzumab vedotin-piiq) is an FDA-approved treatment for adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) who have already received at least 2 prior therapies. It is used in combination with 2 other cancer treatments: bendamustine and a rituximab product (BR).
POLIVY received an accelerated approval from the FDA. This conditional approval helps patients get earlier access to a promising drug while the company continues to conduct clinical trials to establish how the drug works.
POLIVY is a type of medicine called an antibody-drug conjugate, or ADC. POLIVY is designed to work differently from traditional chemotherapies because it has the ability to find dividing B cells, including cancerous B cells.
Almost all B cells (including cancerous ones) have a marker on their surface called CD79b. POLIVY works by finding and attaching to B cells using the CD79b marker.
Illustration of an antibody-drug conjugate (ADC)
*Antibodies are also produced naturally by the body. They are a type of protein that acts as a natural defense system against disease.
POLIVY® is a prescription medicine used with other medicines, bendamustine and a rituximab product, to treat diffuse large B-cell lymphoma in adults who have progressed after at least 2 prior therapies.
The conditional approval of POLIVY is based on a type of response rate. There are ongoing studies to establish how well the drug works.
Everyone reacts differently to POLIVY therapy, so it’s important to know what the side effects are. Some people who have been treated with POLIVY have experienced serious to fatal side effects. Your doctor may stop or adjust your treatment if any serious side effects occur. Be sure to contact your healthcare team if there are any signs of these side effects.
Side effects seen most often
The most common side effects during treatment were
POLIVY may not be for everyone. Talk to your doctor if you are
These may not be all the side effects. Talk to your healthcare provider for more information about the benefits and risks of POLIVY treatment.
You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Genentech at 1-888-835-2555.
Please see the full Prescribing Information for additional Important Safety Information.
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